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Mutation Information
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Mutation Site
|
K601E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Env |
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Viral Reference
|
K03455.1
|
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Relevant Drug
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T1249;T2635;VIR165 |
Literature Information
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PubMed PMID
|
30696772
|
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Published Year
|
2019 |
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Journal
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The Journal of biological chemistry |
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Title
|
HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry. |
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Author
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Eggink D,Bontjer I,de Taeye SW,Langedijk JPM,Berkhout B,Sanders RW |
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Evidence
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Substitutions located at the edge (Q577R) or outside the binding site of HR2-based fusion inhibitors (Q590E, K601E, and N637K) provide resistance to the more potent second and third generation peptides T1249 and T2635.
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HIV Mutation Detail Information