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Mutation Information
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Mutation Site
|
K655M |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Env |
Literature Information
|
PubMed PMID
|
29677220
|
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Published Year
|
2018 |
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Journal
|
PLoS pathogens |
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Title
|
HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G. |
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Author
|
Ikeda T,Symeonides M,Albin JS,Li M,Thali M,Harris RS |
|
Evidence
|
Several of these Env amino acid substitutions occur in the C-terminal heptad repeat region of gp41 (H643Y, T626M, and K655M), and most of the resistance-conferring substitutions match residues observed in transmitted/founder and chronic HIV-1 isolates.
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HIV Mutation Detail Information