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Mutation Information
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Mutation Site
|
K65N |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
lamivudine (LAM) |
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Country
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Spain |
Literature Information
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PubMed PMID
|
33200210
|
|
Disease
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HIV infection/AIDS
|
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Published Year
|
2021 |
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Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Long-term efficacy of dolutegravir plus lamivudine for maintenance of HIV viral suppression in adults with and without historical resistance to lamivudine: Week 96 results of ART-PRO pilot study. |
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Author
|
Rial-Crestelo D,de Miguel R,Montejano R,Dominguez-Dominguez L,Aranguren-Rivas P,Esteban-Cantos A,Bisbal O,Santacreu-Guerrero M,Garcia-Alvarez M,Alejos B,Hernando A,Bermejo-Plaza L,Cadiñanos J,Mayoral M,Castro JM,Moreno V,Martin-Carbonero L,Delgado R,Rubio R,Pulido F,Arribas JR,ART-PRO .,PI16/00837-PI16/00678 study group . |
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Evidence
|
Baseline proviral DNA NGS detected lamivudine RAMs (M184V/I and/or K65R/E/N) above a 5% threshold in 71.4% (15/21) and 15% (3/20) of participants with and without history of lamivudine resistance, respectively.
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HIV Mutation Detail Information