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Mutation Information
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Mutation Site
|
K65R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M184V+rt.K65R |
|
Relevant Drug
|
lamivudine (LAM);didanosine (DDI);abacavir (ABC);tenofovir (TNV) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
20516563
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2010 |
|
Journal
|
Antiviral therapy |
|
Title
|
Clonal resistance analyses of HIV type-1 after failure of therapy with didanosine, lamivudine and tenofovir. |
|
Author
|
Barnas D,Koontz D,Bazmi H,Bixby C,Jemsek J,Mellors JW |
|
Evidence
|
Of the 204 single genome sequences analyzed, 50% were K65R/M184V double-mutants, 38% were M184V single-mutants, 10% were M184I single-mutants, and only 1% (2 sequences) were K65R single-mutants.
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HIV Mutation Detail Information