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Mutation Information
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Mutation Site
|
K65R |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NRTIs |
Literature Information
|
PubMed PMID
|
30174310
|
|
Published Year
|
2018 |
|
Journal
|
Cell chemical biology |
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Title
|
The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase. |
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Author
|
Takamatsu Y,Das D,Kohgo S,Hayashi H,Delino NS,Sarafianos SG,Mitsuya H,Maeda K |
|
Evidence
|
Next, we examined the activity of the 4'-NRTIs against a drug-resistant HIV-1K65R variant because K65R is a TDF resistance-associated mutation that reportedly induces hypersensitivity to EFdA.
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HIV Mutation Detail Information