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Mutation Information
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Mutation Site
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K65R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.K65R+rt.S68G |
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Genotype/Subtype
|
AE |
|
Relevant Drug
|
tenofovir (TDF);lamivudine (LAM);efavirenz (EFV) |
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Country
|
China |
Literature Information
|
PubMed PMID
|
32046664
|
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Disease
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HIV infection/AIDS
|
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Published Year
|
2020 |
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Journal
|
BMC infectious diseases |
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Title
|
The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strains. |
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Author
|
Li S,Ouyang J,Zhao B,An M,Wang L,Ding H,Zhang M,Han X |
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Evidence
|
The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strainsThe rate of S68G mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase has increased and is closely related to the K65R mutation among CRF01_AE-infected patients who failed treatment.
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HIV Mutation Detail Information