|
Mutation Information
|
Mutation Site
|
K70R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Viral Reference
|
K03455.1
|
Literature Information
|
PubMed PMID
|
19005273
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2008 |
|
Journal
|
AIDS (London, England) |
|
Title
|
Silent mutations are selected in HIV-1 reverse transcriptase and affect enzymatic efficiency. |
|
Author
|
Harrigan PR,Sheen CW,Gill VS,Wynhoven B,Hudson E,Lima VD,Lecocq P,Aguirre R,Poon AF,Sluis-Cremer N |
|
Evidence
|
Steady-state kinetic experiments demonstrated that HIV-1 RT exhibited a strong tendency to pause and/or dissociate at codons 65 and 66 on RNA templates that contained the D67N and K70R mutations.
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HIV Mutation Detail Information