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Mutation Information
|
Mutation Site
|
K70R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NRTIs |
|
Country
|
America |
Literature Information
|
PubMed PMID
|
29846534
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
|
Title
|
Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted Human Immunodeficiency Virus Type 1 Drug Resistance in a Large US Clinic Population. |
|
Author
|
Rhee SY,Clutter D,Fessel WJ,Klein D,Slome S,Pinsky BA,Marcus JL,Hurley L,Silverberg MJ,Kosakovsky Pond SL,Shafer RW |
|
Evidence
|
A subset of the NRTI-associated SDRMs were classified as thymidine analogue mutations (TAMs) including M41L, D67N/G, K70R, L210W, T215Y/F, K219Q/E/R/N, and the T215 revertants T215C/D/E/I/S/V (which evolve from T215F/Y in the absence of selective drug pressure).
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HIV Mutation Detail Information