|
Mutation Information
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Mutation Site
|
L100I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
32006797
|
|
Published Year
|
2020 |
|
Journal
|
Bioorganic chemistry |
|
Title
|
Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. |
|
Author
|
Sang Y,Pannecouque C,De Clercq E,Zhuang C,Chen F |
|
Evidence
|
Compound 51 displayed marked inhibitory activity against WT, and mutant L100I, K103N, Y181C, Y188L, and E138K HIV-1 mutants.
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HIV Mutation Detail Information