HIV Mutation Detail Information

> L100I Search Result

Mutation Information

Mutation Site	L100I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	NNRTIs

Literature Information

PubMed PMID	32712537
Published Year	2020
Journal	European journal of medicinal chemistry
Title	Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors.
Author	Chen X,Ding L,Tao Y,Pannecouque C,De Clercq E,Zhuang C,Chen FE
Evidence	Among all the chiral derivatives, (S)-(-)-12a showed the best potency with the antiviral activities against wild-type (WT) and single mutant strains (L100I, K103 N, Y181C, E138K;especially Y188L), and RT enzyme in the low nanomolar concentration range.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation