HIV Mutation Detail Information

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Mutation Information

Mutation Site	L125A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	K03455.1

Literature Information

PubMed PMID	33785631
Published Year	2021
Journal	mBio
Title	Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.
Author	Zhang P,Kwon AL,Guzzo C,Liu Q,Schmeisser H,Miao H,Lin Y,Cimbro R,Huang J,Connors M,Schmidt SD,Dolan MA,Armstrong AA,Lusso P
Evidence	The remaining two mutations, L125A and I309A, selectively affected a single class of antibodies: L125A affected only weakly/nonneutralizing MAbs and sCD4, and I309A affected only trimer-preferring bNAbs, especially PG9 and PG16, in line with previous mutagenesis results.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation