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Mutation Information
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Mutation Site
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L141A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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C |
Literature Information
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PubMed PMID
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33493210
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Published Year
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2021 |
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Journal
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PLoS pathogens |
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Title
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Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication. |
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Author
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Xi J,Luckenbaugh L,Hu J |
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Evidence
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Except for the linker deletion and L140A mutant, which blocked pgRNA packaging and reverse transcription and thus showed no PF DNA (Fig 7A and 7B /lane 2 and 4/), those mutants that showed similar (LC) or reduced (but detectable) RC DNA (L141A, L143I, E145D, TT146/146AA) all showed significantly increased levels of PF-RC DNA and CCC DNA compared to the WT (Fig 7A and 7B /lane 3, 5, 9, 10 and 11/), indicating these mutants increased the formation of CCC DNA and PF-RC DNA (Fig 7C).
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HBV Mutation Detail Information