HBV Mutation Detail Information

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Mutation Information

Mutation Site	L143A
Mutation Type	Amino acid level
Gene/Protein/Region Type	C

Literature Information

PubMed PMID	33493210
Published Year	2021
Journal	PLoS pathogens
Title	Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication.
Author	Xi J,Luckenbaugh L,Hu J
Evidence	L143A, also predicted to impair B56 binding, reduced dephosphorylation at both the A701 and 25-7 epitopes (Fig 2B /lane 8/), while L143I, predicted to maintain B56 binding, did not significantly affect dephosphorylation at either CTD epitope (Fig 2B /lane 9/).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation