|
Mutation Information
|
Mutation Site
|
L146F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Nef |
|
Country
|
UK |
Literature Information
|
PubMed PMID
|
32179688
|
|
Published Year
|
2020 |
|
Journal
|
Proceedings of the National Academy of Sciences of the United States of America |
|
Title
|
Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread. |
|
Author
|
Mesner D,Hotter D,Kirchhoff F,Jolly C |
|
Evidence
|
Nef sequence analysis identified two specific amino acid changes (I123L and L146F) that specifically disrupted the CD3 down-modulation activity.
|
|
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HIV Mutation Detail Information