|
Mutation Information
|
Mutation Site
|
L154A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Env |
|
Viral Reference
|
K03455.1
|
Literature Information
|
PubMed PMID
|
33785631
|
|
Published Year
|
2021 |
|
Journal
|
mBio |
|
Title
|
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State. |
|
Author
|
Zhang P,Kwon AL,Guzzo C,Liu Q,Schmeisser H,Miao H,Lin Y,Cimbro R,Huang J,Connors M,Schmidt SD,Dolan MA,Armstrong AA,Lusso P |
|
Evidence
|
The cluster 1 mutations with the most dramatic impact on neutralization were L154A, L175A, and I322A, while V134A and I326A had a less marked effect with virtually no effect on trimer-preferring bNAbs (Fig. 3A).
|
|
|
HIV Mutation Detail Information