|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
15980328
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2005 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy. |
|
Author
|
Pai SB,Bozdayi AM,Pai RB,Beker T,Sarioglu M,Turkyilmaz AR,Grier J,Yurdaydin C,Schinazi RF |
|
Evidence
|
The major mechanism of resistance has been attributed to the alteration in the YMDD motif of the HBV polymerase due to an amino acid change of rtM204 to V/I and an accompanying rtL180M conversion.
|
|
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HBV Mutation Detail Information