|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);famciclovir (FCV) |
|
Country
|
Mexico |
Literature Information
|
PubMed PMID
|
16373428
|
|
Disease
|
HBV infection
|
|
Published Year
|
2006 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Genotypic resistance to lamivudine among hepatitis B virus isolates in Mexico. |
|
Author
|
Alvarado-Esquivel C,de la Ascensión Carrera-Gracia M,Conde-González CJ,Juárez-Figueroa L,Ruiz-Maya L,Aguilar-Benavides S,Torres-Valenzuela A,Sablon E |
|
Evidence
|
The isolate from the hepatitis patient showed a double mutation at codon positions 180 (L180M) and 204 (M204V), thus a 2.6% prevalence of genotypic resistance to lamivudine was found.
|
|
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HBV Mutation Detail Information