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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rt.M204V+rt.S202G+rt.L180M;rt.M204V+rt.L180M+rt.V173L;rt.M204V+rt.S202G+rt.A181G+rt.L180M;rt.M204V+rt.S202G+rt.L180M+rt.P177S+rt.V173L;rt.M204V+rt.S202G+rt.I169L+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
|
PubMed PMID
|
17239478
|
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis
|
|
Published Year
|
2007 |
|
Journal
|
Journal of hepatology |
|
Title
|
Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient. |
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Author
|
Villet S,Ollivet A,Pichoud C,Barraud L,Villeneuve JP,Trépo C,Zoulim F |
|
Evidence
|
The rtV173L+L180M+M204V dominant mutant displayed strong lamivudine-resistance and the highest replication capacity.
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HBV Mutation Detail Information