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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M250V+rt.L180M+rt.M204V |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
18435459
|
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Disease
|
HBV infection
|
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Published Year
|
2008 |
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Journal
|
Hepatology (Baltimore, Md.) |
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Title
|
Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance. |
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Author
|
Baldick CJ,Tenney DJ,Mazzucco CE,Eggers BJ,Rose RE,Pokornowski KA,Yu CF,Colonno RJ |
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Evidence
|
Two of these substitutions are associated with lamivudine resistance (LVDr) in the tyrosine-methionine-aspartate-aspartate (YMDD) motif (rtM204V and rtL180M), whereas the other occurs at one or more positions specifically associated with ETV resistance (ETVr): rtT184, rtS202, or rtM250.
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HBV Mutation Detail Information