|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rt.M204I+rt.L180M |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
telbivudine (LDT);lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
19028525
|
|
Published Year
|
2009 |
|
Journal
|
Antiviral research |
|
Title
|
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir. |
|
Author
|
Seifer M,Patty A,Serra I,Li B,Standring DN |
|
Evidence
|
Telbivudine was not active against HBV strains bearing lamivudine mutations L180M/M204V/I but remained active against the M204V single mutant in vitro, potentially explaining the difference in resistance profiles between telbivudine and lamivudine.
|
|
|
HBV Mutation Detail Information