|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
21396961
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2011 |
|
Journal
|
Journal of virological methods |
|
Title
|
HBV DNA replication mediated by cloned patient HBV reverse transcriptase genes from HBV genotypes A-H and its use in antiviral phenotyping assays. |
|
Author
|
Zhu Y,Curtis M,Borroto-Esoda K |
|
Evidence
|
Recombinants expressing patient derived RT genes containing the rtL180M+M204V lamivudine resistance (LAM-R) mutations demonstrated a LAM-R phenotype.
|
|
|
HBV Mutation Detail Information