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Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181V+rt.L180M+rt.I163V;rt.M204V+rt.L180M;rt.M204V+rt.S202G+rt.T184A+rt.L180M;rt.M204I+rt.L180M |
|
Relevant Drug
|
adefovir (ADV);lamivudine (LAM);entecavir (ETV) |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
21911882
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2011 |
|
Journal
|
Annals of hepatology |
|
Title
|
Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B. |
|
Author
|
Arrese E,Basaras M,Blanco S,Ruiz P,Cisterna R |
|
Evidence
|
RESULTS: Three patients developed LAM resistance mutations (2 presented rtM204I and one rtL180M+rtM204V/I) and one patient showed rtN236T ADV resistance mutation.
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HBV Mutation Detail Information