|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V173L+rt.L180M+rt.M204V |
|
Genotype/Subtype
|
E |
|
Viral Reference
|
X75664.1
|
Literature Information
|
PubMed PMID
|
22195774
|
|
Clinical information
|
Yes
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2011 |
|
Journal
|
BMC research notes |
|
Title
|
Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa. |
|
Author
|
Stewart B,Jobarteh ML,Sarge-Njie R,Alabi A,de Silva T,Peterson K,Peterson I,Whittle H,Rowland-Jones S,Jaye A,Cotten M,Mendy M |
|
Evidence
|
One patient showed the M204V+ L180M+ V174L+ triple mutation associated with a vaccine escape phenotype, which could be of public health concern in a country with a national HBV vaccination programme.
|
|
|
HBV Mutation Detail Information