|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M+rt.V173L |
|
Viral Reference
|
X02763
|
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
23454647
|
|
Disease
|
HBV infection
|
|
Published Year
|
2013 |
|
Journal
|
Journal of virological methods |
|
Title
|
Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach. |
|
Author
|
Bhattacharya D,Lewis MJ,Lassmann B,Phan T,Knecht G,Bickel M,Yang OO |
|
Evidence
|
Detection of minor variant viral quasispecies of the rtV173L+rtL180M+rtM204V combination mutation in the hepatitis B virus (HBV) polymerase mediating both lamivudine resistance and vaccine escape is potentially important for tracking the development and evolution of resistance within both individuals and populations.
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HBV Mutation Detail Information