|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
25028473
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
The Journal of general virology |
|
Title
|
Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility. |
|
Author
|
Fan J,Wang Y,Xiong H,Guo X,Cheng YC |
|
Evidence
|
Replication-competent HBV constructs containing rtI187V and combined with LAM-resistant (rtM204I, rtL180M/rtM204V) mutations were generated, and compared with WT, LAM-resistant single (rtM204I) or double (rtL180M/rtM204V) and ADV-resistant (rtN236T) clones.
|
|
|
HBV Mutation Detail Information