|
Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rt.M204V+rt.L180M+rt.V173L |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
India |
Literature Information
|
PubMed PMID
|
25654813
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2015 |
|
Journal
|
Antiviral therapy |
|
Title
|
High incidence of lamivudine-resistance-associated vaccine-escape HBV mutants among HIV-coinfected patients on prolonged antiretroviral therapy. |
|
Author
|
Pal A,Sarkar N,Saha D,Guha SK,Saha B,Chakrabarti S,Chakravarty R |
|
Evidence
|
Three major patterns of mutations in HBV polymerase gene, namely single (rtM204V), double (rtL180M+rtM204V) and triple (rtV173L+rtL180M+rtM204V) mutations, are associated with 3TC-resistance; additionally, the triple mutation has vaccine-escape potential due to a corresponding change in overlapping surface gene.
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HBV Mutation Detail Information