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Mutation Information
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Mutation Site
|
L180M |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.S202G+rt.M204V+rt.L180M |
Literature Information
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PubMed PMID
|
26336997
|
|
Published Year
|
2015 |
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Journal
|
Current medicinal chemistry |
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Title
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Mechanism of Adefovir, Tenofovir and Entecavir Resistance: Molecular Modeling Studies of How A Novel Anti-HBV Agent (FMCA) Can Overcome the Drug Resistance. |
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Author
|
Rawal RK,Konreddy AK,Chu CK |
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Evidence
|
In this regard, homology modeled structure of HBV polymerase was used for minimization, conformational search and Glide XP docking followed by binding energy calculation on wild-type as well as on mutant HBV-polymerases (N236T, L180M+M204V+S202G & A194T).
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HBV Mutation Detail Information