|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M;rt.M204I+rt.M204V+rt.L180M;rt.S202G+rt.M204I+rt.M204V+rt.L180M;rt.T184A+rt.M204I+rt.M204V+rt.L180M |
|
Genotype/Subtype
|
B;C |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
29119303
|
|
Disease
|
HBV infection
|
|
Published Year
|
2018 |
|
Journal
|
Virus genes |
|
Title
|
Evolution of drug-resistant mutations in HBV genomes in patients with treatment failure during the past seven years (2010-2016). |
|
Author
|
Zhang HY,Liu LG,Ye CY,Chen CH,Hang SX,Zhu Z,Shen HY,Huang ZY,Chen WY,Xue Y |
|
Evidence
|
For single-base mutations, rtL180M and rtA181V increased gradually during the past seven years, while rtM204I/V and rtN236T decreased after 2015.
|
|
|
HBV Mutation Detail Information