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Mutation Information
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Mutation Site
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L180M |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.M204V+rt.L180M;rt.L180M+rt.M204I;rt.L180M+rt.M204V |
|
Relevant Drug
|
entecavir (ETV);adefovir (ADV);telbivudine (LDT);tenofovir (TDF);lamivudine (LAM) |
Literature Information
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PubMed PMID
|
30202825
|
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Disease
|
HBV infection
|
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Published Year
|
2018 |
|
Journal
|
Hepatology communications |
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Title
|
Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis. |
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Author
|
Rose RE,Hernandez D,Falk PJ,Ericson K,Zhou N,Thiry A,McPhee F |
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Evidence
|
Previous studies revealed that ETV-resistant (ETVr) HBV DNA resulted from substitutions in the HBV reverse transcriptase (RT) at positions rtT184, rtS202, or rtM250 in combination with lamivudine resistance (LVDr) substitutions rtM204I/V+/-rtL180M.
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HBV Mutation Detail Information