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Mutation Information
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Mutation Site
|
L180Q |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
32868329
|
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Published Year
|
2020 |
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Journal
|
Antimicrobial agents and chemotherapy |
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Title
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Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. |
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Author
|
Huang Q,Cai D,Yan R,Li L,Zong Y,Guo L,Mercier A,Zhou Y,Tang A,Henne K,Colonno R |
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Evidence
|
In vitro analysis of qPCR and Southern blot data demonstrated that the rtL180M/M204V mutant strain displayed a 10- to 12-fold shift in susceptibility to ETV compared with the wild-type virus (Table 4 and Fig. S4), which was similar to previous results with other 3TC-resistant strains (rtL180Q/M204V) (19).
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HBV Mutation Detail Information