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Mutation Information
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Mutation Site
|
L369K |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Env |
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Viral Reference
|
K03455.1
|
|
Immune Escape
|
Y |
Literature Information
|
PubMed PMID
|
30709739
|
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Published Year
|
2019 |
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Journal
|
Immunity |
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Title
|
An Antigenic Atlas of HIV-1 Escape from Broadly Neutralizing Antibodies Distinguishes Functional and Structural Epitopes. |
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Author
|
Dingens AS,Arenz D,Weight H,Overbaugh J,Bloom JD |
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Evidence
|
Further, I326Y and L369K escaped VRC01 in BG505 but not LAI (also validated in TZM-bl assays in Figure S7D), while mutations to site 474 generally have a larger effect in LAI than in BG505 (Figure S7B).
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HIV Mutation Detail Information