|
Mutation Information
|
Mutation Site
|
L528M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
famciclovir (FCV);lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10418752
|
|
Published Year
|
1999 |
|
Journal
|
International journal of antimicrobial agents |
|
Title
|
Perspectives for the treatment of hepatitis B virus infections. |
|
Author
|
De Clercq E |
|
Evidence
|
Yet, famciclovir and lamivudine may lead to the emergence of resistance mutations (i.e. L528M and M552V/I) in the HBV DNA polymerase upon long-term treatment.
|
|
|
HBV Mutation Detail Information