HBV Mutation Detail Information

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Mutation Information

Mutation Site	L528M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Combined Mutation	p.M552V+p.M552I+p.L528M
Viral Reference	X51970
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	11020004
Disease	Chronic hepatitis B
Published Year	2000
Journal	Journal of hepatology
Title	Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance.
Author	Gutfreund KS,Williams M,George R,Bain VG,Ma MM,Yoshida EM,Villeneuve JP,Fischer KP,Tyrrel DL
Evidence	In the majority of lamivudine-resistant isolates the mutations have been reported to occur within the YMDD motif of the viral polymerase, either as a single mutation M552I or as M552V concomitant with L528M.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation