HBV Mutation Detail Information

> L528M Search Result

Mutation Information

Mutation Site	L528M
Mutation Type	Amino acid level
Gene/Protein/Region Type	P
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	9593029
Disease	Chronic hepatitis B
Published Year	1998
Journal	The Journal of infectious diseases
Title	Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment.
Author	Niesters HG,Honkoop P,Haagsma EB,de Man RA,Schalm SW,Osterhaus AD
Evidence	Analysis of the HBV DNA polymerase gene from 8 chronic hepatitis B patients with suspected resistance to lamivudine showed that in addition to a mutation in the YM552DD motif, a second mutation located in the B domain of this gene, a Leu528-to-Met528 change, was consistently and exclusively found in 4 patients showing the YV552DD motif.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation