|
Mutation Information
|
Mutation Site
|
L528M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Combined Mutation
|
p.M552V+p.L528M |
|
Amino acid_Mutation
|
T2076A |
|
Viral Reference
|
X02763.1
|
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV);famciclovir (FCV) |
Literature Information
|
PubMed PMID
|
9828233
|
|
Published Year
|
1998 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro. |
|
Author
|
Xiong X,Flores C,Yang H,Toole JJ,Gibbs CS |
|
Evidence
|
HBV DNA polymerase mutants M552I, M552V, and L528M/M552V showed resistance to lamivudine triphosphate with inhibition constants (Ki) increased by 8.
|
|
|
HBV Mutation Detail Information