|
Mutation Information
|
Mutation Site
|
L552M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Viral Reference
|
X51970
|
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
11020004
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2000 |
|
Journal
|
Journal of hepatology |
|
Title
|
Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance. |
|
Author
|
Gutfreund KS,Williams M,George R,Bain VG,Ma MM,Yoshida EM,Villeneuve JP,Fischer KP,Tyrrel DL |
|
Evidence
|
Breakthrough viremia was not observed with the single L528M substitution but occurred with the appearance of M552V/L552M.
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|
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HBV Mutation Detail Information