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Mutation Information
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Mutation Site
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L80V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
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lamivudine (LAM);adefovir (ADV) |
Literature Information
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PubMed PMID
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22505793
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Published Year
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2011 |
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Journal
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International journal of current chemistry |
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Title
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Hepatitis B Virus genotypic differences map structurally close to NRTI resistance hot spots. |
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Author
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Michailidis E,Singh K,Kirby KA,Hachiya A,Yoo W,Hong SP,Kim SO,Folk WR,Sarafianos SG |
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Evidence
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The L80V/I mutation causes resistance to LVD and ADV. It is proximal to three residues that vary among different genotypes: a) residue 217, which is a leucine (L) in all genotypes except for genotype A where it is an arginine (R); b) residue 242, which is an arginine (R) in all genotypes except for genotype H where it is a tryptophan (W); c) residue 221, which was also discussed in Cluster I.
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HBV Mutation Detail Information