HIV Mutation Detail Information

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Mutation Information

Mutation Site	L89M
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR
Combined Mutation	pr.L89M+pr.G48T
Genotype/Subtype	B
Relevant Drug	atazanavir (ATV)

Literature Information

PubMed PMID	30560871
Published Year	2018
Journal	Scientific reports
Title	Characterizing early drug resistance-related events using geometric ensembles from HIV protease dynamics.
Author	Sheik Amamuddy O,Bishop NT,Tastan Bishop Ö
Evidence	Previous work described distinct mechanisms associated with ARV drug resistance that all point to active site expansion, namely (1) impaired hydrophobic sliding shown in the G48T/L89M double mutant with saquinavir, (2) reduced dimer stability in L24I, I50V and F53L mutants and (3) single or co-operative distal mutations.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation