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Mutation Information
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Mutation Site
|
M120V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PreS2 |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
X02496;
AB074755;
D00329;
M57663 |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
20962085
|
|
Disease
|
Hepatocellular carcinoma
|
|
Published Year
|
2011 |
|
Journal
|
Journal of virology |
|
Title
|
Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections. |
|
Author
|
Mun HS,Lee SA,Kim H,Hwang ES,Kook YH,Kim BJ |
|
Evidence
|
For the elucidation of molecular and cellular mechanisms related to link between hepatocellular carcinoma (HCC) and expression of F141L-LHBs, we constructed three types of stable hepatoma cell lines (Huh-7 cells) constitutively expressing LHBs of the wild type (WT), LHBs carrying both the F141L and the pre-S2 start M120V mutation (Mut1), or LHBs with the F141L mutation alone (Mut2).
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HBV Mutation Detail Information