|
Mutation Information
|
Mutation Site
|
M130K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
X |
|
Genotype/Subtype
|
F |
|
Viral Reference
|
AB036919
|
Literature Information
|
PubMed PMID
|
16080797
|
|
Disease
|
Acute hepatitis B;
Chronic hepatitis B;
Hepatocellular carcinoma
|
|
Published Year
|
2005 |
|
Journal
|
Virology journal |
|
Title
|
HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers. |
|
Author
|
León B,Taylor L,Vargas M,Luftig RB,Albertazzi F,Herrero L,Visona K |
|
Evidence
|
A change in the amino acid sequences at positions 130 and 131 in the HBV-X protein (M130K and V131I) produced by T-A point mutations at the nucleic acids level has been associated with severe liver damage and HCC in patients from China and Africa.
|
|
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HBV Mutation Detail Information