HIV Mutation Detail Information

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Mutation Information

Mutation Site	M184I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	C
Viral Reference	K03455.1
Relevant Drug	NRTIs
Country	Congo

Literature Information

PubMed PMID	32045455
Disease	HIV infection/AIDS
Published Year	2020
Journal	PloS one
Title	HIV-1 subtypes and drug resistance mutations among female sex workers varied in different cities and regions of the Democratic Republic of Congo.
Author	Kwon EH,Musema GMA,Boelter J,Townsend S,Tshala-Katumbay D,Kayembe PK,West J,Wood C
Evidence	Subtype A1 was prevalent (40%) in Goma located in the East and significantly higher than in Mbuji-Mayi (p<0.05) in the South-central region, or in Lubumbashi in the South. Antiretroviral resistance was detected in 21.5% of 93 pol sequences analyzed, with the M184I/V and K103N mutations that confer high-level resistance to NRTI and NNRTI, respectively, being the most frequent mutations. However, the K103N mutant viruses were found only in the East.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation