HIV Mutation Detail Information

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Mutation Information

Mutation Site	M184V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Immune Escape	Y
Relevant Drug	NRTIs
Country	America

Literature Information

PubMed PMID	28604824
Disease	HIV infection/AIDS
Published Year	2017
Journal	PloS one
Title	Decline in CD4 T lymphocytes with monotherapy bridging strategy for non-adherent adolescents living with HIV infection: Results of the IMPAACT P1094 randomized trial.
Author	Agwu AL,Warshaw MG,McFarland EJ,Siberry GK,Melvin AJ,Wiznia AA,Fairlie L,Boyd S,Harding P,Spiegel HML,Abrams EJ,Carey VJ,P1094 Study Team.
Evidence	One strategy has been using 3TC/ FTC monotherapy (3TC/FTC), which in the presence of the M184V resistance mutation, does not suppress viral replication nor select for additional drug resistance mutations, and reduces viral fitness with limited side effects.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation