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Mutation Information
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Mutation Site
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M184V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
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NRTIs |
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Country
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Italy |
Literature Information
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PubMed PMID
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29977967
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Disease
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HIV infection/AIDS
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Published Year
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2018 |
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Journal
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Open forum infectious diseases |
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Title
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Impact of the M184V Resistance Mutation on Virological Efficacy and Durability of Lamivudine-Based Dual Antiretroviral Regimens as Maintenance Therapy in Individuals With Suppressed HIV-1 RNA: A Cohort Study. |
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Author
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Gagliardini R,Ciccullo A,Borghetti A,Maggiolo F,Bartolozzi D,Borghi V,Pecorari M,Di Biagio A,Callegaro AP,Bruzzone B,Saladini F,Paolucci S,Maserati R,Zazzi M,Di Giambenedetto S,De Luca A,ARCA Study Group . |
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Evidence
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Impact of the M184V Resistance Mutation on Virological Efficacy and Durability of Lamivudine-Based Dual Antiretroviral Regimens as Maintenance Therapy in Individuals With Suppressed HIV-1 RNA: A Cohort StudyDual therapy (DT) with boosted protease inhibitors (bPIs) plus lamivudine has been shown to be superior to bPI monotherapy in virologically suppressed patients despite previous selection of the lamivudine resistance M184V mutation.
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HIV Mutation Detail Information