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Mutation Information
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Mutation Site
|
M184V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
NRTIs;amprenavir (APV) |
Literature Information
|
PubMed PMID
|
32182845
|
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Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance. |
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Author
|
Yeo JY,Goh GR,Su CT,Gan SK |
|
Evidence
|
For example, the M184V resistance mutation in HIV-1 RT is known to increase fidelity, impair viral fitness, and increase hyper-sensitization to NRTIs (such as amprenavir and efavirenz).
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HIV Mutation Detail Information