|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
15720534
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2005 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
Three-phase sequential combined treatment with lamivudine and interferon in young patients with chronic hepatitis B. |
|
Author
|
Marrone A,Zampino R,Portella G,Grimaldi M,Durante-Mangoni E,Santarpia L,Ruggiero G,Utili R |
|
Evidence
|
After IFN withdrawal, viraemia transiently increased to high levels in five of 11 (45%) patients who showed rt M204V/I lamivudine mutant resistant.
|
|
|
HBV Mutation Detail Information