|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+s.W196L;s.S207R+s.W196L |
|
Amino acid_Mutation
|
G741T |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
India |
Literature Information
|
PubMed PMID
|
16428891
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
Intervirology |
|
Title
|
Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India. |
|
Author
|
Kazim SN,Sarin SK,Sharma BC,Khan LA,Hasnain SE |
|
Evidence
|
Drug resistance was diag-nosed only when rtYM204I/VDD substitution within the viral polymerase was detected by direct DNA sequencing, irrespective of the viral DNA or ALT profi le at that time.
|
|
|
HBV Mutation Detail Information