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Mutation Information
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Mutation Site
|
M204I |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.M204V+rt.L180M+rt.L173V;rt.M204I+rt.M204V+rt.L180M |
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Relevant Drug
|
lamivudine (LAM) |
Literature Information
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PubMed PMID
|
16549970
|
|
Disease
|
HBV-HIV coinfection
|
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Published Year
|
2006 |
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Journal
|
AIDS (London, England) |
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Title
|
Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy. |
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Author
|
Matthews GV,Bartholomeusz A,Locarnini S,Ayres A,Sasaduesz J,Seaberg E,Cooper DA,Lewin S,Dore GJ,Thio CL |
|
Evidence
|
Three main patterns of Pol mutations were identified: rtM204I (single; n = 5), rtL180M + rtM204V/I (dual; n = 25), and rtV173L + rtL180M + rtM204V (triple; n = 9).
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HBV Mutation Detail Information