|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
entecavir (ETV);lamivudine (LAM);telbivudine (LDT) |
Literature Information
|
PubMed PMID
|
18435459
|
|
Disease
|
HBV infection
|
|
Published Year
|
2008 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance. |
|
Author
|
Baldick CJ,Tenney DJ,Mazzucco CE,Eggers BJ,Rose RE,Pokornowski KA,Yu CF,Colonno RJ |
|
Evidence
|
Patient isolates were also found with rtT184 substitutions in the LVDr rtM204I background, but these were limited to rtT184 S or I substitutions and yielded average ETV EC50 values of 39 and 43 nM, respectively.
|
|
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HBV Mutation Detail Information