HBV Mutation Detail Information

> M204I Search Result

Mutation Information

Mutation Site	M204I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	lamivudine (LAM);entecavir (ETV)
Country	Japan

Literature Information

PubMed PMID	22523569
Disease	Chronic hepatitis B
Published Year	2012
Journal	PloS one
Title	Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing.
Author	Nishijima N,Marusawa H,Ueda Y,Takahashi K,Nasu A,Osaki Y,Kou T,Yazumi S,Fujiwara T,Tsuchiya S,Shimizu K,Uemoto S,Chiba T
Evidence	Moreover, various abundances of clones resistant to NA were common in both the liver and serum of treatment-naive patients, and the proportion of M204VI mutants resistant to lamivudine and entecavir expanded in response to entecavir treatment in the serum of 35.7% (5/14) of patients, suggesting the putative risk of developing drug resistance to NA.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation