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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Viral Reference
|
X02763.1
|
|
Country
|
China |
Literature Information
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PubMed PMID
|
24348637
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2013 |
|
Journal
|
Hepatitis monthly |
|
Title
|
Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance. |
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Author
|
Qin B,Zhang B,Zhang X,He T,Xu W,Fu L,Tu C |
|
Evidence
|
To further analyze the influence of the rtQ267H on HBV replication and sensitivity to LMV, MT HBV replication-competent plasmids, pHBV-rtQ267H, -rtL180M, -rtM204V, -rtM204I, -rtL180M/M204V, -rtL180M/Q267H, -rtM204V/Q267H, -rtL180M/M204V/Q267H were constructed based on pHBV1.3. MT HBV plasmids were then transfected into Huh7 cells, respectively.
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HBV Mutation Detail Information